Activated protein C resistance ratio

Company Reagent Link to information Remarks
American Diagnostica APC

Method: Clotting

Activator: Russell’s viper venom factor V dependent prothrombin activator

FV deficient plasma: No

American Diagnostica ACTICLOT APC-R Kit

Method: Clotting

Activator: Russell’s viper venom factor V dependent prothrombin activator

Interferences:  No interference of UFH, LMWH and pentasaccharide

FV deficient plasma: No

American Diagnostica OLIGOBIND APC

Method: EIA

FV deficient plasma: No

BioMedica diagnostics ACTICLOT Protein C Resistance

Method: Clotting

Activator: Russell’s viper venom factor V dependent prothrombin activator

Interferences:  No interference of UFH, LMWH and pentasaccharide

FV deficient plasma: No

Chromogenix Coatest APC Resistance

Method: Clotting

Activator: activated protein C and calcium

FV deficient plasma: No

Chromogenix Coatest APC Resistance V

Method: Clotting

Assay principle: activated protein C and calcium

Interferences: No interference of heparin or oral anticoagulant therapy

FV deficient plasma: Yes

DG APC

Method: Clotting

Activator: Notechis scutatus snake venom factor V dependent prothrombin activator

FV deficient plasma: No

Diagen PCA kit

Method: Clotting

Activator: Snake venom agkistrodon contortrix

FV deficient plasma: Yes and No

Helena Biosciences PCA Ratio Kit

Method: Clotting

Acivator: activated protein C and calcium

FV deficient plasma: Yes

ImmBioMed OLIGOBIND APC activity assay

Method: EIA

FV deficient plasma: No

Instrumentation Laboratory, Werfen HemosIL Factor V Leiden (APCR) IL HemosIL Factor V Leiden (APCR)

Method: Clotting

Activator: Activated protein C and calcium

Interferences: No interference of heparin up to 1 U/mL and oral anticoagulant therapy

FV deficient plasma: Yes

Hyphen BioMed Hemoclot Quanti V-L Hyphen Quanti V-L

Method: Clotting

Activator: Factor Xa in presence of phospholipids and calcium

FV deficient plasma: Yes

Hyphen BioMed Hemoclot V-L

Method: Clotting

Activator: Purified factor IXa with phospholipids and calcium

FV deficient plasma: No

Life Diagnostics GradiLeiden V kit

Method: Clotting

Activator: Snake venom agkistrodon contortrix

Interferences: No interference of heparin and oral anticoagulant therapy

Pentapharm Pefakit APC-R Factor V Leiden Penthapharm Pefakit APC-R FVL

Method: Clotting

Activator: A snake venom factor Va dependent prothrombin activator

Interferences: No interference of UFH, LMWH and pentasaccharide

FV deficient plasma: No

REA-Clot APC-R (V) REA-Clot APC-R (V)

Method: Clotting

Interferences: Interference of UFH and Lupus

FV deficient plasma: Yes

Renam ReaPrC/FV

Method: Clotting

Activator: Activated protein C and calcium

FV deficient plasma: Yes

Roche  APC Resistance

Method: Clotting

FV deficient: No

Siemens Healthineers ProC Ac R Siemens ProC Ac R

Method: Clotting

Activator: Snake venom agkistrodon contortrix

FV deficient plasma: No

Siemens Healthineers ProC Global Siemens ProC global

Method: Clotting

Activator: Snake venom agkistrodon contortrix

Interferences: No interference of heparin up to 0.8 U/mL, (Without factor V deficient plasma sensitive to deficiencies of factor V Leiden, proteine C and S, certain lupus anticoagulants and high factor VII levels)

FV deficient plasma: Yes

Stago  STA-Staclot APC-R Stago STA-Staclot APC-R

Method: Clotting

Activator: Crotalus viridis helleri venom

Interferences: Interference of low Factor V (<50%) and thrombin inhibitors, no interference of heparin up to 1.0 U/mL.

FV deficient plasma: Yes

Technoclone APC Resistance kit Technoclone APC Resistance kit

Method: Clotting

Activator: A snake venom factor Va dependent prothrombin activator

Interferences: Interference of low Factor V (<50%) and thrombin inhibitors, no interference of heparin up to 2.0 U/mL and Lupus

FV deficient plasm

FV deficient plasma: No