Activator II V VII X

Company Reagent Link to information Remarks
BioMedica Diagnostics QuikCoag PT-HS Reagent: Lyophilized

Reagent source: Calcified rabbit brain tromboplastin

ISI: 0.9 – 1.5

Diamed Diaplastin E Reagent: Liquid

Reagent source: Rabbit brain combined with Calcium/Thromboplastin

ISI: In the range of 1.1

Interferences: High sensitivity to Factor II, V, VII, X

Hart Biologicals Ultrasense PT

Reagent: Liquid

Reagent source: Recombinant thromboplastin

Sensitivity: sensitive to extrinsic factors, insensitive to therapeutic levels of heparin

ISI: Approximately 1.0

Helena Biosciences Thromboplastin

Reagent: Lyophilized

Reagent Source: Rabbit brain tissue

ISI: Range 2.0 – 2.5

Helena Biosciences Thromboplastin L

Reagent: Liquid

Reagent Source:  Calcified rabbit brain tromboplastin

ISI: Range approximately 1.1

Interferences: Insensitive up to 2 U/ml of Heparin

Hyphen BioMed (h) PT-Phen Hyphen (h) PT-Phen

Reagent: Lyophilized

Reagent source: Thromboplastin  (containing
recombinant human tissue factor, synthetic phospholipids and calcium)

ISI: Range 0.9 – 1.1

Instrumentation Laboratory, Werfen HemosIL PT- Fibrinogen IL HemosIL PT-Fibrinogen

Reagent: Lyophilized

Reagent source: Rabbit-brain

ISI: Range approximately 2.0

Interferences: Insensitive up to 1.0 U/ml of Heparin

Instrumentation Laboratory, Werfen HemosIL PT-Fibrinogen – HS Plus IL HemosIL PT-Fibrinogen HS Plus

Reagent: Lyophilized

Reagent source: Rabbit-brain

ISI: Range approximately 1.2

Interferences: Insensitive up to 0.5 U/ml of Heparin, extrinsic factor sensitive

Instrumentation Laboratory, Werfen HemosIL ReadiPlasTin IL HemosIL ReadiPlasTin

Reagent: Liquid

Reagent source: Recombinant human tissue factor

Interferences: Insensitive up to 1.0 U/ml of Heparin

Instrumentation Laboratory, Werfen HemosIL RecombiPlasTin 2G IL HemosIL RecombiPlasTin 2G

Reagent: Liquid

Reagent source: Recombinant human tissue factor

ISI: Range approximately 1.0

Interferences:  Insensitive up to 1.0 U/ml of Heparin, extrinsic factor sensitive.

MediRox MRX Owren’s PT

Reagent: Lyophilized

Reagent source: Based on bovine plasma

Interferences:  Insensitive up to 1.0 U/ml of Heparin

Nycomed Thrombotest

Reagent: Lyophilized

Reagent source: Bovine brain thromboplastin and adsorbed bovine plasma

ISI: 1.0

Interferences: Sensitive to the depression of factors II, VII and X as well as to the presence of PIVKA factors

Nycomed Nycotest

Reagent: Lyophilized

Reagent source: Rabbit brain thromboplastin and adsorbed bovine plasma

ISI: 1.0

Interferences: Sensitive to the depression of factors II, VII and X. Insensitive to heparin in therapeutic doses

Pacific Hemostasis Thromboplastin-DS

Reagent: Lyophilized

Reagent source: Rabbit brain tissue

ISI: Range 1.0 – 1.3

Sekisui Coagpia PT-N

Reagent: Lyophilized

Reagent Source: Rabbit brain tissue

ISI: Range approximately 1.0

Interferences: High factor sensivity

Siemens Healthineers Innovin Siemens Innovin

Reagent: Lyophilized

Reagent source: Purified recombinant human tissue factor combined with synthetic phospholipids

Interferences: High sensitive to extrinsic factor deficiences and oral anti-coagulant. Insensitive up to 2.0 U/ml of Heparin

Siemens Healthineers Thromboplastin C Plus Siemens Thromboplastin C Plus Reagent: Lyophilized

Reagent source: Dried rabbit brain thromboplastin

Siemens Healthineers Thromborel S Siemens Thromborel S

Reagent: Lyophilized

Reagent source: Human placental thromboplastin

Interferences: High sensitive to factor II, V, VII and X. Insensitive up to 0.5 U/ml of Heparin

Stago Neoplastine CI

Reagent: Lyophilized

Reagent source: Thromboplastin prepared from fresh rabbit cerebral tissues

Interferences: The reagent exhibits a low turbidity and does not sediment, insensitive to heparin

Stago Néoplastine CI Plus Stago Néoplastine CI Plus

Reagent: Lyophilized

Reagent source: Thromboplastin prepared from fresh rabbit cerebral tissues

ISI: Range approximately 1.3

Interferences: The reagent exhibits a low turbidity and does not sediment, insensitive up to 1.0 U/ml of Heparin

Stago STA-Néoplastine CI

Reagent: Lyophilized

Reagent source: Thromboplastin prepared from fresh rabbit cerebral tissues

Interferences: Insensitive to heparin

Stago STA- Néoplastine CI Plus

Reagent: Lyophilized

Reagent source: Thromboplastin prepared from fresh rabbit cerebral tissues

Interferences: Insensitive to heparin

Stago STA-Néoplastine R Stago STA-Néoplastine R

Reagent: Lyophilized

Reagent source: Thromboplastin (human recombinant tissue factor and phospholipids)

ISI: Range approximately 1.0

Insensitive up to 1.0 U/ml of Heparin

Stago STA-NeoPTimal Stago STA-NeoPTimal

Reagent: Lyophilized

Reagent source: Thromboplastin prepared from rabbit brain extract

ISI: Range approximately 1.0

Insensitive up to 1.0 U/ml of Heparin

Stago, Tcoag TriniCLOT PT Excel Stago TriniClot PT Exel Reagent: Lyophilized

Reagent source: Thromboplastin from either rabbit or human sources

ISI: Range 1.8 – 2.0

Stago, Tcoag TriniCLOT PT Excel S Stago TriniClot PT Exel S Reagent: Lyophilized

Reagent source: Thromboplastin from either rabbit or human sources

ISI: Range 1.0 – 1.2

Stago, Tcoag TriniCLOT PT HTF Stago TriniClot PT HTF Reagent: Lyophilized

Reagent source: Thromboplastin from either rabbit or human sources

ISI: Range approximately 1.0

Technoclone Technoclot PT Plus Technoclone Technoclot PT Plus

Reagent: Lyophilized

Reagent source: Rabbit brain tissue

ISI: < 1.2

Interferences: Sensitive to  factors II, V, VII and X. Insensitive up to 0.5 U/ml of Heparin

Technoclone Technoplastin HIS Technoclone Technoplastin HIS

Reagent: Lyophilized

Reagent source: Rabbit brain tissue

ISI: < 1.2

Interferences: Sensitive to factors II, V, VII and X. Insensitive up to 1.0 U/ml of Heparin

ThermoFisher scientific Pacific Hemostasis Thromboplastin-DS

Reagent: Lyophilized

Reagent source: Rabbit brain tissue

ISI: Range 1.0 – 1.3

Tokra MTI PT with calcium

Reagent: Lyophilized

Reagent source: Rabbit brain thromboplastin

ISI: Range 1.0 – 1.4

Tokra MTI PT Thromboplast

Reagent: Liquid

Reagent source: Rabbit brain thromboplastin

ISI: Range 1.0 – 1.3

Tokra MTI PT Thromboplast HR

Reagent: Liquid

Reagent source: Recombinant rabbit brain thromboplastin

ISI: Range 0.8 – 1.0