Protein C activity

Company Reagent Link to information Remarks
Am. Diagnostica Protac C

Method: Endpoint-clotting assay

Activator: Derived from the venom of the viper agkistrodon contortrix

American Diagnostica ACTICHROME

Method: Chromogenic

American Diagnostica ACTICLOT

Method: Clotting

BioMedica Diagnostics ACTICLOT

Method: Clotting

Activator: Derived from the venom of the viper agkistrodon contortrix

Chromogenix Coamatic Protein C

Method: Chromogenic

Activator: Derived from the venom of the viper agkistrodon contortrix

Interferences: No interference of heparin levels up tot 3 IU/ml

Grifols DG-Chrom PC

Method: Chromogenic

Activator: Derived from the venom of the viper agkistrodon contortrix

Hart Biologicals Protein C Clotting Assay Kit

Method: End-point clotting assay

Helena Biosciences Protein C

Method: Chromogenic

Activator: Derived from the venom of the viper agkistrodon contortrix

Helena Chromz Protein C

Method: Chromogenic

Hyphen BioMed Biophen Protein C Hyphen Biophen Protein C

Method: Chromogenic

Activator: Derived from the venom of the viper agkistrodon contortrix

Interferences: No interference for heparin <  1 IU/mL, bilirubin < 60 mg/dL, hemoglobin < 500 mg/dL and intralipids concentration < 1000 mg/dL. Aprotinin or presence of anti-human Protein C antibodies may decrease the measured Protein C activity.

Hyphen BioMed Hemoclot Protein C Hyphen Hemoclot Protein C

Method: Clotting

Activator: Derived from the venom of the viper agkistrodon contortrix

Interferences: No interference for heparin <  1 IU/mL. Special caution should be taken for patients with known high levels of FVIII:C or with LA

Instrumentation Laboratory, Werfen HemosIL Proclot C IL HemosIL ProClot

Method: Clotting

Activator: Derived from the venom of the viper agkistrodon contortrix

Interferences: No interference from heparin (LMW) up to 0.7 U/mL,  heparin (UF) up to 1.5 U/mL, hemoglobin < 200 mg/dL, bilirubin < 25 mg/dL and triglycerides < 600 mg/dL.
Protein C results may be affected by LA and high levels of factor VIII (>250%) and APC-R

Instrumentation Laboratory, Werfen HemosIL Protein C IL HemosIL Protein C

Method: Chromogenic

Activator: Derived from the venom of the viper agkistrodon contortrix

Interferences: no interference from heparin (UF or LMW heparin) < 2 U/mL,
hemoglobin < 200/500 mg/dL, triglycerides < 500/890 mg/dL and bilirubin 5/ 21 mg/dL. ACL Classic/ACL TOP.

Nordic Biomarker MRX Protein C

Method: Chromogenic

Activator: Protein C activator

Interferences:  No interference from heparin < 2 U/ml, bilirubin ≤20 mg/dL, haemoglobin ≤200 mg/dL, triglycerides ≤350 mg/dL

Pentapharm Protac Protac

Method: Chromogenic and clotting

Activator: Derived from the venom of the viper agkistrodon contortrix

Precision Biologic Chromocheck Protein C

Method: Chromogenic

Activator: Derived from the venom of the viper agkistrodon contortrix

Precision Biologic Cryocheck Clot C Precision Biologic Cryocheck Clot C

Method: Clotting

Activator: Russell’s viper venom (RVV-X)

Interferences: No interference of factor VIII:C activity levels < 600% and heterozygous factor VLeiden mutation

Reanal-Ker Bioclot Protein C
Roche Protein C Chrom

Method: Chromogenic

Activator: Snake venom

Siemens Healthineers  Berichrom Protein C Siemens Berichrom Protein C

Method: Chromogenic

Activator: Derived from the venom of the viper agkistrodon contortrix

Interferences: False low protein C activity may be obtained in patients being treated with aprotinin

Siemens Healthineers Protein C Reagent Siemens Protein C Reagent

Method: Clotting

Activator: Derived from the venom of the viper agkistrodon contortrix

Interferences: False low protein C activity may be obtained in patients being treated with aprotinin.

Stago STA_Stachrom Protein C

Method: Chromogenic

Activator: Derived from the venom of the viper agkistrodon contortrix

Interferences: No interference from hemoglobin <
2 g/l, bilirubin < 200 mg/l and triglycerides < 4 g/l.

Stago STA-Staclot Protein C Stago STA-Staclot Protein C

Method: Clotting

Activator: Derived from the venom of the viper agkistrodon contortrix

Interferences: No interference from heparin < 1 U/ml, LA,  factor VIII:C activity levels < 250%. Trombin inhibitors may interference

Stago, Tcoag TriniCLOT Protein C II Stago TriniCLOT Protein C II

Method: Clotting

Activator: Derived from the venom of the viper agkistrodon contortrix

Stago,Tcoag  TriniCHROM Protein C

Method: Chromogenic

Activator: Derived from the venom of the viper agkistrodon contortrix

Technoclone  Technochrom Protein C Technoclone Technochrom Protein C

Method: Chromogenic

Activator: Derived from the venom of the viper agkistrodon contortrix

Interferences: No interference from heparin < 2 U/ml

Technoclone  Technoclot Protein C Technoclone Technoclot Protein C

Method: Clotting

Activator: Derived from the venom of the viper agkistrodon contortrix