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Today we are pleased to send you our digital Newsletter which aims to provide you with some important ECAT information and relevant articles in the fields of quality control and/ or laboratory diagnosis in thrombosis & haemostasis.
Enjoy reading.
Petra van Velp
Survey Manual 2022

The Survey Manual 2022 is now available at our website. To get access to the Survey Manual, please go to the Participant Area, select Survey reports, Download Reports and Login. In the top menu you see the option View Documents. Select this option.

At the bottom of the page you will see a section with useful documents. Here you can find your Survey Manual. If you want you can download the document and store it on your own pc or make a print of the document.
New: Wildcard Programme

In 2022 the ECAT will start with a new survey programme: Wildcard Programme.
The Wildcard Programme is meant for all kind of haemostasis parameters for which no ECAT external quality assessment programme exist, for instance for rare analytes which are only measured by a few laboratories. Example of these parameters are: Prekallikrein, HMW Kinonogen, Plasminogen antigen, Fibrinogen antigen, Fibrin Monomer etc.
With this Wildcard Programme we offer the participant a possibility to compare their results with those of other laboratories. The participant can make their own selection for which parameters they want to use this programme as long as the parameter is not a part of any other ECAT programme. Only haemostasis parameters, including contact activation parameters will be evaluated.
This survey will run together with the third survey period 2022 (6 September – 4 October). The cost for participation is € 325,=. You can still register for this programme.
If you want to join this survey and have not yet registered, please contact the ECAT office:
New: Bivariate Z-score analysis

Starting in 2022 the ECAT introduces in the survey evaluations the so-called bivariate Z-score analysis. This analysis looks into the correlation of the Z-score pairs from all participants. These Z-score pairs are obtained from the results of two samples included in a survey. An example of such a bivariate Z-score plot is shown here:

At ECAT Information in this newsletter you will find a detailed explanation of the bivariate Z-score analysis.
New: Publication

The study of the ECAT Foundation, in close collaboration with the Erasmus Medical Center in Rotterdam, on the impact of COVID-19 pandemic on the quality of test output in haemostasis laboratories has now been published in the International Journal of Laboratory Hematology. This open-access publication can be reached by the following link:

ECAT Information:
Bivariate Z-score Analysis 

The original application of statistical monitoring external quality assessment (EQA) result according to the ISO 17043 standard involves the evaluation of the deviation of the result measured from the assigned value. In the ECAT EQA programme this is done by the calculation of the Z-score, which represents the deviation as a measure of how many times the standard deviation the result deviates from the assigned value [Z-score = (result – assigned value)/standard deviation]. Read more 

Case Report:
Acquired von Willebrand disease and marginal zone lymphoma 

A 48-year-old male was diagnosed with marginal zone lymphoma stage IVB with massive splenomegaly (14 cm under rib cage), no palpable hepatomegaly, B-symptoms (night sweats), and bone marrow invasion. Histological evaluation showed hypercellular bone marrow with diffuse, dense infiltration of PAX5++, CD20++ , CD10-, CD5- lymphoma cells. Initially, a treatment protocol consisting of rituximab, cyclophosphamide, vincristine, and prednisone (R-CVP) was initiated with a planned re-evaluation after 4 cycles of R-CVP. However, after 1 cycle of R-CVP, the treatment was upgraded to rituximab, cyclophosphamide, vincristine, doxorubicin, and prednisone scheme 21 (R-CHOP) due to insufficient treatment response. Read more

Literature Highlights:
Recent publications

Below we list some interesting recent publications in the field of thrombosis and haemostasis, and laboratory diagnostics. Because of the enormous number of publications we have limited our reporting to just a small list of interesting publications. It is not our intention to provide you with a complete overview. We hope this list supports you in your awareness of interesting publications.

- Liu, Y., Z. Shao and H. Wang, SARS-CoV-2 vaccine-induced immune thrombotic thrombocytopenia. Thromb Res, 2022; 209: 75-79. 
- Favaloro, E.J., L. Pasalic and G. Lippi, Review and evolution of guidelines for diagnosis of COVID-19 vaccine induced thrombotic thrombocytopenia (VITT). Clin Chem Lab Med, 2022; 60: 7-17.
Laboratory testing
- Tanaka, K.A., R. Henderson, K. Thangaraju, Y. Morita, M.A. Mazzeffi, E. Strauss, et al., In vitro effects of emicizumab on activated clotting time in blood samples from cardiac surgical patients. Haemophilia, 2022; 28: 183-190. 
- Capdevila, L., C. Frere, M. Desvages, A. Harroche, C. Bally, A. Abbes, et al., Emicizumab does not interfere with the activated clotting time. Haemophilia, 2022; 28: 362-366. 
- Roginski, E., P.H. Nissen, J.A. Hojbjerg, E.L. Grove and A.M. Hvas, Impact of centrifugation time and pneumatic tube transport on plasma concentrations of direct oral anticoagulants. Int J Lab Hematol, 2022; 44: 216-222. 
- Marin, M.J., N. Harris and W. Winter, A Rational Approach to Coagulation Testing. Lab Med, 2022 (DOI: 10.1093/labmed/lmac005)
- Yang, D., Z. Su and M. Zhao, Big data and reference intervals. Clin Chim Acta, 2022; 527: 23-32.
- Paal, M., K. Habler and M. Vogeser, Estimation of inter-laboratory reference change values from external quality assessment data. Biochem Med (Zagreb), 2021; 31: 030902.
Upcoming Events


02-04 April 2022, Washington DC,

Labquality Days

20-21 April 2022, Helsinki,



22th Annual NATA Symposium

28-30 April 2022, Athens,

WFH 2022 World Congress

08-11 May 2022, Montreal,

XXX ISTH and 68th SSC

09-13 July 2022, London,

For more events, please have a look into our Calendar.

March 2022, Issue 22
ECAT Foundation
ECAT Information
Case Report
Literature Highlights
Upcoming Events
Diagnostic Corner
Pharma Corner
Editor in Chief:
P. van Velp

Editorial Board:
P. van Velp
P. Meijer

Advisory Committee:
K. Devreese
D. Peetz
A. Stroobants

+31.(0)71.3030910 9
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